Ingrid Kohlstadt MD, MPH and Kenneth Cintron MD, MBA: Editing Metabolic Therapies in Orthopedics, 2nd Edition

Regenerative Orthopedics and Metabolism

Metabolic Therapies in Orthopedics, 2nd Edition

The innate healing power of the human body amazes the most erudite of physicians and the most skilled of surgeons.  Physicians and surgeons are no longer limited to observing, describing and quantifying the body’s regenerative potential, as practiced since Antiquity.  Therapies of the 21st Century accelerate the human body’s self-healing mechanisms.

Metabolic Therapies in Orthopedics, 2nd Edition is a 30-thought-leader collaboration to translate metabolic research into clinic-ready therapies for regenerating the musculoskeletal system from within. The book’s premise is that:

  • Regenerative orthopedic therapies merit clinical study and have a future in 21st Century medicine including sports medicine, recovery from trauma and surgery, disease of degeneration, adverse effects of medications and toxins.
  • Therapies intended to accelerate the body’s healing mechanisms are more likely to restore musculoskeletal function in the presence of metabolic wellness.
  • Currently available evidence-based treatments improve patients’ metabolism. Such therapies are underutilized if outside the modern pharmacocentric medical framework.

The first edition published in 2006 is entitled Scientific Evidence for Musculoskeletal, Bariatric and Sports Nutrition and it synthesized the evidence that forms the basis for this edition which includes ready applications for regenerative therapies.  The second edition probes newly arising questions such as these:

  • How to design PRP clinical studies in light of established benefits of metabolic wellness?
  • For what patients is bone mineral density a poor marker of bone strength?
  • How is laser therapy applied in orthopedics and might its metabolic changes be used in conjunction with regenerative therapies?
  • What integrative strategies can help patients transition from pharmacotherapies known to impair regenerative orthopedic processes?
  • How can adverse impact of obesity on the musculoskeletal system be minimized and the body’s innate regenerative mechanisms supported?

Lastly, “What is the role of your book in the Information Age when quickly accessible, free information is but a click away?”  This was the reply Dr. Kohlstadt received when she asked Dr. George Lundberg for feedback on the book’s first edition. Her answer remains unflinched – synthesis, clarity and credibility.


Written by doctors for doctors, readers and authors bridge shared collective knowledge and authors frame their diligent research with clinical experience.  From a purely practical perspective alone the book is a timesaver, because it is an unprecedented synthesis spanning informatics, genomics, microbiology, ecology, biophysics, agriculture and pharmacology.


How much longer does it take to bring breakthroughs to our patients because of the confusion caused by commercial and other biases? Headlines report experts disagree, consensus documents are ineffectively bland, research summaries conclude only that more studies are needed, and internet searches draw conflicting interpretations. This book harmonizes the expert opinions of 30 thought leaders.  The unforced agreement provides readers with clarity for patient care, business decisions, and research directions.


The evidence presented in an evenhanded manner by vetted clinicians and researchers provides a credibility recognized by patients, administrators and business strategists.

In sum, the direction-setting of this book creates vision and strategies. The authors have gathered a broad range of studies and clinical experiences looking for patterns, relationships and linkages that help explain the biological and regenerative processes in our ecosystem.

What is crucial about the authors’ vision is how well it serves the interest of important constituencies of the healthcare system, patients and families, providers, the community- and how easily it can be translated into a realistic medical practice. They “walk the talk” providing empowerment by teaching effective, safe and valuable practice guidelines.

Posted on: March 6, 2017, by : Ellis